Table I.

Skin graft rejection in BALB/c SCID recipients of B6 trunk skin allografts after adoptive transfer of T cellsa

Cells InjectedTime to Rejection (days)
Unfractionated T cells
Naive12, 13, 12, 13
Primed in culture with B6 stimulators plus IL-4 and anti-IFN-γ13, 14, 15, 21
CD4+ T cells
Naive9, 10, 10, 12
Primed in culture with B6
plus IL-4 and anti-IFN-γ27, 29, 29, 26, 28
CD8+ T cells
Naive11, 12
Primed in culture with B6 stimulators
plus IL-4 and anti-IFN-γ27, 25, 24, >30b , >30b
  • a Recipient mice were injected with 1–3 × 106 T cells by i.v. injection into the tail vein.

  • b These two grafts showed focal evidence of hair loss but were not fully rejected by visual inspection at sacrifice on day 30. Both showed histologic evidence of diffuse mononuclear cell infiltration consistent with rejection.