Table I.

Adoptive immunotherapy of 3-day established pulmonary MCA 205 metastases with tumor-draining LN cells separated based on L-selectin expression

CellsaNo. TransferredNo. Metastasesb
Unfractionated10 × 1060
Unfractionated3 × 106≥250
L-selectin+10 × 106≥250
L-selectin3 × 1060
  • a Cells from inguinal LN draining a progressive MCA 205 tumor were separated and activated by the anti-CD3/IL-2 method and given i.v. to mice bearing 3-day pulmonary MCA 205 metastases.

  • b Lungs were harvested and metastases counted on day 21.