Table II.

Blind test of the predictive power of the DRB1*0401 algorithm

Selection CriteriaNo. of Peptides
Binding affinityaTotalχ2(p)
HighIntermediateNegative
None3113650b
P1-P63928400.177 (NS)
0.734c3871810.28 (<0.01)
2.617d342916.36 (<0.005)
  • a High binding corresponds to an IC50 ≤100 nM, intermediate binding corresponds to an IC50 in the 100 to 1000 nM range, and negative binding refers to affinity >1000 nM.

  • b Not applicable.

  • c Algorithm score that predicts 90% of all binders.

  • d Algorithm score that predicts 75% of all binders.