Table IV.

Recognition of peptide analogs by Melan-A-specific CTL clonesa

Peptide SequenceRecognition by CTL Clone
M77.867.10Mel 1.33M77.801.13
Peptide [nM] 50%Relative ActivityPeptide [nM] 50%Relative ActivityPeptide [nM] 50%Relative ActivityPeptide [nM] 50%Relative ActivityPeptide [nM] 50%Relative Activity
AAGIGILTV1515013001300140001
ALGIGILTV900.16>1000<0.015>1000<0.3>1000<0.3>10000<0.4
AMGIGILTV>1000<0.015>1000<0.015>1000<0.3>1000<0.3>10000<0.4
LAGIGILTV0.081871.53315020.0310000301300
MAGIGILTV0.6251532001.50.56008050
EAAGIGILTV0.151004120.0650006000.520002
EALGIGILTV3000.05>1000<0.015407.5>1000<0.3>10000<0.4
EAMGIGILTV0.5301500.02150005605080
ELAGIGILTV0.01510000.51000.015200000.560020200
EMAGIGILTV55036>1000<0.015407.5>1000<0.3>10000<0.4
YAAGIGILTV0.0151000351.4>1000<0.310000.3>10000<0.4
FAAGIGILTV0.005300077>1000<0.3>1000<0.320020
  • a Relative antigenic activity of Melan-A-derived peptides was measured as described in the legends to Figure 4 and Table III.