Table III.

Both tumor cells and host-derived APC present tumor-encoded Ag to CD4+ T cells in A/J→F1 and B6→F1 bone marrow chimeric micea

Expt. No.Tumor CellsChimeraT Cell DepletionT Cell: APC RatioIL-2 (pg/ml)
A/J APCC57BL/6 APC
1SaI/Ab/HELA/J→F110:155357
50:1607520
2SaI/Ab/HELA/J→F110:1430172
3SaI/Ab/HELA/J→F1CD810:1217137
CD410:17.34
4SaI/Ak/HELB6→F110:113233
5SaI/Ak/HELB6→F1CD810:10197
CD410:1010.6
  • a A/J→F1 or B6→F1 bone marrow chimeric mice were challenged i.p. with SaI/Ab/HEL or SaI/Ak/HEL tumor cells, respectively, and splenic T cells were tested in vitro for IL-2 production in response to lysozyme plus I-Ab (C57BL/6) or I-Ak (A/J) APC, respectively. In some experiments, responding T cells were depleted for CD4+ or CD8+ T cells prior to assay.