Table II.

Neutralization of PLP80-88.3 chemotactic activitya

Neutralizing AntiseraExp. 1, Inhibition of Cell Migration (%)Exp. 2, Inhibition of Cell Migration (%)Exp. 3, Inhibition of Cell Migration (%)
Anti-IP-1057 (p = 0.00017)b36 (p = 0.0008)59 (p = 0.002)
Anti-IL-1621 (p = 0.0045)21 (p = 0.007)17 (p = 0.029)
Anti-MIP-1α06 (p = 0.47)10 (p = 0.41)
Anti-MIP-1β5 (p = 0.06)11 (p = 0.25)7 (p = 0.21)
  • a CD4+ T cells in experiments 1 and 2 were PLP40-60.1 and in experiment 3 were GD22. Percent cell migration values in the absence of added antibodies were: experiment 1, 1116%; experiment 2, 381%; and experiment 3, 677%.

  • bp values represent comparisons to % cell migration in the absence of antibody.