Table II.

Contributions of T cell subsets to protective immunity against influenza B virus challenge infection in DI micea

1° Virus: Treatment:Mean Log10 Lung Virus, TCID50/gm Tissue (No. of Mice with Undetectable Lung Virus/Total Mice)
B/AA ControlB/AA Anti-CD4B/AA Anti-CD8B/AA Anti-CD4 + anti-CD8None None
Days postchallenge
DI mice
Day 51.9 ± 0.22.7 ± 0.2b2.4 ± 0.33.4 ± 0.4b3.2 ± 0.5b
(4/6)(1/8)(3/8)(1/7)(2/7)
Day 7≤1.5 ± 01.9 ± 0.32.8 ± 0.5b3.5 ± 0.6b3.1 ± 0.6b
(6/6)(5/7)(3/8)(1/6)(2/6)
B6 mice
Day 5≤1.5 ± 0≤1.5 ± 0≤1.5 ± 0≤1.5 ± 04.1 ± 0.3b
(8/8)(8/8)(8/8)(8/8)(0/7)
Day 7≤1.5 ± 0≤1.5 ± 0≤1.5 ± 0≤1.5 ± 02.8 ± 0.4b
(8/8)(8/8)(8/8)(8/8)(3/7)
  • a Mice were primed and challenged with flu B/AA, as described in Table I, or with PBS in the control group. T cell subset depletions were performed as shown in Figure 1, at days −3, −1, and +2 relative to challenge. Mice for day +7 analysis received an additional depletion at day +5. Titer indicated as ≤1.5 only if all animals in group had undetectable virus. Otherwise, geometric means were calculated and t tests performed as in Table I.

  • b Significantly different from group in the same row treated with control ascites; by t test, p < 0.05.