Table I.

Histopathology of spinal cords from 1,25-(OH)2D3-treated and control mice

Days PostimmunizationDays PosttreatmentHistopathology ScoreaEAE Severity
Control1,25-(OH)2D3Control1,25-(OH)2D3
1472.4 ± 0.5b0.3 ± 0.44.5 ± 0.0b0.8 ± 0.6
(n = 5)(n = 3)(n = 5)(n = 3)
21141.6 ± 0.81.0 ± 0.71.8 ± 1.00.5 ± 0.7
(n = 8)(n = 3)(n = 8)(n = 3)
  • a Inflammation along the CNS was scored blindly and given a value of 0, 1, 2, or 3 for the degree of inflammation. EAE was scored as previously described (7). Numbers are the mean ± SD for each group of mice (n).

  • b Control values are significantly higher than 1,25-(OH)2D3 values.