RT Journal Article
SR Electronic
T1 Anti-inflammatory activity of Tribulus terrestris in RAW264.7 Cells (54.2)
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 54.2
OP 54.2
VO 188
IS 1 Supplement
A1 Oh, Joa Sub
A1 Baik, Seung Ho
A1 Ahn, Eun-Kyung
A1 Jeong, Wonsik
A1 Hong, Seong Su
YR 2012
UL http://www.jimmunol.org/content/188/1_Supplement/54.2.abstract
AB Inflammation is involved in various diseases, including chronic inflammatory disease and arthritis. The inflammation induced by the production of cyclooxygenease (COX)-2 and inducible nitric oxide synthase (iNOS), which are important mediators of inflammation. In this study, we investigated the ethanol extract of Tribulus terrestris (ETT) inhibited expression of COX-2 and iNOS in lipopolysaccharide(LPS)- stimulated RAW264.7 cells. We observed that ETT significantly decreased release of NO production in a dose-dependent manner in LPS-stimulated RAW264.7 cells. ETT also suppressed expression of proinflammtory cytokines, such as TNF-α and IL-4 in macrophage cell line. Our findings suggest that ETT inhibits expression of mediators related to inflammation and expression of inflammatory cytokines, which has a beneficial effect on various inflammatory diseases.