PT  - JOURNAL ARTICLE
AU  - Oh, Joa Sub
AU  - Baik, Seung Ho
AU  - Ahn, Eun-Kyung
AU  - Jeong, Wonsik
AU  - Hong, Seong Su
TI  - Anti-inflammatory activity of Tribulus terrestris in RAW264.7 Cells (54.2)
DP  - 2012 May 01
TA  - The Journal of Immunology
PG  - 54.2--54.2
VI  - 188
IP  - 1 Supplement
4099  - http://www.jimmunol.org/content/188/1_Supplement/54.2.short
4100  - http://www.jimmunol.org/content/188/1_Supplement/54.2.full
SO  - J. Immunol.2012 May 01; 188
AB  - Inflammation is involved in various diseases, including chronic inflammatory disease and arthritis. The inflammation induced by the production of cyclooxygenease (COX)-2 and inducible nitric oxide synthase (iNOS), which are important mediators of inflammation. In this study, we investigated the ethanol extract of Tribulus terrestris (ETT) inhibited expression of COX-2 and iNOS in lipopolysaccharide(LPS)- stimulated RAW264.7 cells. We observed that ETT significantly decreased release of NO production in a dose-dependent manner in LPS-stimulated RAW264.7 cells. ETT also suppressed expression of proinflammtory cytokines, such as TNF-α and IL-4 in macrophage cell line. Our findings suggest that ETT inhibits expression of mediators related to inflammation and expression of inflammatory cytokines, which has a beneficial effect on various inflammatory diseases.