PT  - JOURNAL ARTICLE
AU  - Montecino-Rodriguez, Encarnacion
AU  - Dorshkind, Kenneth
TI  - Formation of B-1 B Cells from Neonatal B-1 Transitional Cells Exhibits NF-κB Redundancy
AID  - 10.4049/jimmunol.1102416
DP  - 2011 Dec 01
TA  - The Journal of Immunology
PG  - 5712--5719
VI  - 187
IP  - 11
4099  - http://www.jimmunol.org/content/187/11/5712.short
4100  - http://www.jimmunol.org/content/187/11/5712.full
SO  - J. Immunol.2011 Dec 01; 187
AB  - The stages of development leading up to the formation of mature B-1 cells have not been identified. As a result, there is no basis for understanding why various genetic defects, and those in the classical or alternative NF-κB pathways in particular, differentially affect the B-1 and B-2 B cell lineages. In this article, we demonstrate that B-1 B cells are generated from transitional cell intermediates that emerge in a distinct neonatal wave of development that is sustained for ∼2 wk after birth and then declines as B-2 transitional cells predominate. We further show that, in contrast to the dependence of B-2 transitional cells on the alternative pathway, the survival of neonatal B-1 transitional cells and their maturation into B-1 B cells occurs as long as either alternative or classical NF-κB signaling is intact. On the basis of these results, we have generated a model of B-1 development that allows the defects in B-1 and B-2 cell production observed in various NF-κB–deficient strains of mice to be placed into a coherent cellular context.