RT Journal Article
SR Electronic
T1 The <em>in Vitro</em> and <em>in Vivo</em> Effects of Cortisol on Interferon Production and Action
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 345
OP 352
VO 96
IS 2
A1 Mendelson, Jack
A1 Glasgow, Lowell A.
YR 1966
UL http://www.jimmunol.org/content/96/2/345.abstract
AB Using the plaque reduction assay for interferon, it was found that cortisol inhibited inter feron production in infections with either an RNA (Chikungunya) or a DNA (vaccinia) virus in vitro. The depression of interferon production was not associated with an increased rate of virus replication. There was no effect of cortisol on the anti-viral activity of interferon in vitro. In vivo, the injection of cortisol 1 hr before an experimental viremia significantly reduced the amount of interferon in the sera of mice 4.5 to 6 hr after infection.