PT  - JOURNAL ARTICLE
AU  - Mendelson, Jack
AU  - Glasgow, Lowell A.
TI  - The <em>in Vitro</em> and <em>in Vivo</em> Effects of Cortisol on Interferon Production and Action
DP  - 1966 Feb 01
TA  - The Journal of Immunology
PG  - 345--352
VI  - 96
IP  - 2
4099  - http://www.jimmunol.org/content/96/2/345.short
4100  - http://www.jimmunol.org/content/96/2/345.full
SO  - J. Immunol.1966 Feb 01; 96
AB  - Using the plaque reduction assay for interferon, it was found that cortisol inhibited inter feron production in infections with either an RNA (Chikungunya) or a DNA (vaccinia) virus in vitro. The depression of interferon production was not associated with an increased rate of virus replication. There was no effect of cortisol on the anti-viral activity of interferon in vitro. In vivo, the injection of cortisol 1 hr before an experimental viremia significantly reduced the amount of interferon in the sera of mice 4.5 to 6 hr after infection.