RT Journal Article
SR Electronic
T1 The Relation Between Isolated Human Amyloid Fibrils and Human γ-Globulin and Its Subunits
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 239
OP 244
VO 96
IS 2
A1 Cathcart, Edgar S.
A1 Cohen, Alan S.
YR 1966
UL http://www.jimmunol.org/content/96/2/239.abstract
AB Purified amyloid fibrils from three separate spleens obtained from patients with primary and secondary disease were used to determine the relation between human amyloid fibrils and human γ-globulin and its subunits. Results demonstrated no reaction a) when solubilized amyloid fibrils were tested against specific antisera to whole human γ-globulin and some of its components; b) when specific components of human γ-globulin were tested against antiserum to solubilized amyloid fibrils and c) when intact lyophilized amyloid fibrils were tested against specific antisera to whole human γ-globulin and some of its components. The probable nonspecific relation of amyloid fibrils to γ-globulin was discussed.