PT  - JOURNAL ARTICLE
AU  - Shands, J. W.
AU  - Stalder, H.
AU  - Suter, E.
TI  - Clearance of <em>Salmonella Typhimurium</em> in Mice and Immunity to Mouse Typhoid: A Comparison of the Activities of Hyperimmune Rabbit γ-Globulin and Porter's Fragment I Obtained by Papain Hydrolysis
DP  - 1966 Jan 01
TA  - The Journal of Immunology
PG  - 68--73
VI  - 96
IP  - 1
4099  - http://www.jimmunol.org/content/96/1/68.short
4100  - http://www.jimmunol.org/content/96/1/68.full
SO  - J. Immunol.1966 Jan 01; 96
AB  - Fragment I was isolated from rabbit γ-globulin which contained antibodies to Salmonella. On a weight basis the fragment I and γ-globulin were compared as to their ability to promote phagocytosis, protect mice against infection with Salmonella typhimurium, and prepare bacteria for the bactericidal effect of complement. Fragment I retains 1 to 2% of the activity of intact γ-globulin in clearance and protection tests. It retains no activity in the bactericidal test nor in the sensitization of red cells for complement lysis. Although certain components of complement may be involved, the complete system as defined by hemolytic activity or bactericidal activity is not essential either for opsonization of Salmonella or for preparation for in vivo kill.