RT Journal Article
SR Electronic
T1 Alteration of the Specificity of Lectin by Chemical Modification. II
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 25
OP 28
VO 96
IS 1
A1 Matsubara, Shoji
A1 Boyd, William C.
YR 1966
UL http://www.jimmunol.org/content/96/1/25.abstract
AB The effects on the blood group specificity of lima bean anti-A of coupling to it diazotized amino derivatives of D-glucose and D-galactose were investigated. The galactose derivatives all enhanced the anti-B activity, p-aminophenyl-α-N-acetyl-D-galactosaminide (Ga III) being the most effective. Some of the glucose derivatives also enhanced the anti-B activity, but tended more to confer also an anti-O activity. The anti-B activity of these modified lectins was inhibited by 1 M d-galactose, and all activity inhibited by N - acetyl - d - galactosamine. Possible chemical mechanisms of the observed changes are discussed.