RT Journal Article
SR Electronic
T1 Adjuvant Properties of Bacterial Cell Wall Mucopeptides
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 134
OP 138
VO 96
IS 1
A1 Holton, Juanita Bird
A1 Schwab, John H.
YR 1966
UL http://www.jimmunol.org/content/96/1/134.abstract
AB Antibody production in rabbits against BSA, as measured by passive hemagglutination, gel diffusion and skin reaction, is enhanced when injected with saline suspensions of mucopeptide derived from the cell walls of β-hemolytic streptococci. The mucopeptide is more effective than comparable doses of cell walls or soluble cell extract. The best antibody response is obtained when the interval between mucopeptide and antigen injections is less than 24 hr. The adjuvant effect is local rather than systemic, since the antigen must be injected into the same skin site as mucopeptide. The mucopeptide has no effect on the immunoglobulin category in which antibody is found.