PT  - JOURNAL ARTICLE
AU  - Briody, B. A.
AU  - Cassel, William A.
AU  - Medill, Mary A.
TI  - Adaptation of Influenza Virus to Mice
DP  - 1955 Jan 01
TA  - The Journal of Immunology
PG  - 41--45
VI  - 74
IP  - 1
4099  - http://www.jimmunol.org/content/74/1/41.short
4100  - http://www.jimmunol.org/content/74/1/41.full
SO  - J. Immunol.1955 Jan 01; 74
AB  - The egg lines of the Seerey Type A prime and the SSM Type B strains of influenza virus are sensitive to the hemagglutinin (HA)-inhibiting and the in ovo neutralizing activity of the β inhibitor in normal ox serum. Adaptation of the Seerey and SSM strains to CF1, CFW, and NIH mice is accompanied by the development of resistance to the HA-inhibiting and neutralizing effect of β inhibitor. The sudden and concomitant nature of the appearance of extensive pulmonary consolidation in 4 days and the development of resistance to HA-inhibition and neutralization by β inhibitor suggests that these changes are interrelated. Virus resistant to β inhibitor has also been isolated by passage of sensitive virus in eggs in the presence of ox serum.