PT  - JOURNAL ARTICLE
AU  - Do, Jeong-su
AU  - Visperas, Anabelle
AU  - Dong, Chen
AU  - Baldwin, William M.
AU  - Min, Booki
TI  - Cutting Edge: Generation of Colitogenic Th17 CD4 T Cells Is Enhanced by IL-17<sup>+</sup> γδ T Cells
AID  - 10.4049/jimmunol.1004021
DP  - 2011 Apr 15
TA  - The Journal of Immunology
PG  - 4546--4550
VI  - 186
IP  - 8
4099  - http://www.jimmunol.org/content/186/8/4546.short
4100  - http://www.jimmunol.org/content/186/8/4546.full
SO  - J. Immunol.2011 Apr 15; 186
AB  - Th 17 cells have been implicated in the pathogenesis of colitis; however, a cellular mechanism by which colitogenic Th17 immunity arises in vivo remains unclear. In this study, we report that a subset of IL-17+ γδ T cells plays a crucial role in enhancing in vivo Th17 differentiation and T cell-mediated colitis. TCRβ−/− mice were highly susceptible to T cell-mediated colitis, whereas TCRβδ−/− mice were resistant to the disease. Importantly, cotransfer of IL-17+ but not of IL-17− γδ T cells with CD4 T cells was sufficient to enhance Th17 differentiation and induce full-blown colitis in TCRβδ−/− recipients. Collectively, our results provide a novel function of IL-17+ γδ T cell subsets in supporting in vivo Th17 differentiation and possibly in fostering the development of intestinal inflammation.