RT Journal Article
SR Electronic
T1 Cutting Edge: A Critical Functional Role for IL-23 in Psoriasis
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 5688
OP 5691
DO 10.4049/jimmunol.1001538
VO 185
IS 10
A1 Tonel, Giulia
A1 Conrad, Curdin
A1 Laggner, Ute
A1 Di Meglio, Paola
A1 Grys, Katarzyna
A1 McClanahan, Terrill K.
A1 Blumenschein, Wendy M.
A1 Qin, Jian-Zhong
A1 Xin, Hong
A1 Oldham, Elizabeth
A1 Kastelein, Robert
A1 Nickoloff, Brian J.
A1 Nestle, Frank O.
YR 2010
UL http://www.jimmunol.org/content/185/10/5688.abstract
AB Interleukin-23 is a key cytokine involved in the generation of Th17 effector cells. Clinical efficacy of an anti-p40 mAb blocking both IL-12 and IL-23 and disease association with single nucleotide polymorphisms in the IL23R gene raise the question of a functional role of IL-23 in psoriasis. In this study, we provide a comprehensive analysis of IL-23 and its receptor in psoriasis and demonstrate its functional importance in a disease-relevant model system. The expression of IL-23 and its receptor was increased in the tissues of patients with psoriasis. Injection of a mAb specifically neutralizing human IL-23 showed IL-23–dependent inhibition of psoriasis development comparable to the use of anti-TNF blockers in a clinically relevant xenotransplant mouse model of psoriasis. Together, our results identify a critical functional role for IL-23 in psoriasis and provide the rationale for new treatment strategies in chronic epithelial inflammatory disorders.