RT Journal Article
SR Electronic
T1 Role of MyD88 in Route-Dependent Susceptibility to Vesicular Stomatitis Virus Infection
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 5173
OP 5181
DO 10.4049/jimmunol.178.8.5173
VO 178
IS 8
A1 Zhou, Shenghua
A1 Kurt-Jones, Evelyn A.
A1 Fitzgerald, Katherine A.
A1 Wang, Jennifer P.
A1 Cerny, Anna M.
A1 Chan, Melvin
A1 Finberg, Robert W.
YR 2007
UL http://www.jimmunol.org/content/178/8/5173.abstract
AB TLRs are important components of the innate immune response. The role of the TLR signaling pathway in host defense against a natural viral infection has been largely unexplored. We found that mice lacking MyD88, an essential adaptor protein in TLR signaling pathway, were extremely sensitive to intranasal infection with vesicular stomatitis virus, and this susceptibility was dose dependent. We demonstrated that this increased susceptibility correlates with the impaired production of IFN-α and defective induction and maintenance of neutralizing Ab. These studies outline the important role of the TLR signaling pathway in nasal mucosae-respiratory tracts-neuroepithelium environment in the protection against microbial pathogen infections. We believe that these results explain how the route of infection, probably by virtue of activating different cell populations, can lead to entirely different outcomes of infection based on the underlying genetics of the host.