PT  - JOURNAL ARTICLE
AU  - Zerafa, Nadeen
AU  - Westwood, Jennifer A.
AU  - Cretney, Erika
AU  - Mitchell, Sally
AU  - Waring, Paul
AU  - Iezzi, Manuela
AU  - Smyth, Mark J.
TI  - Cutting Edge: TRAIL Deficiency Accelerates Hematological Malignancies
AID  - 10.4049/jimmunol.175.9.5586
DP  - 2005 Nov 01
TA  - The Journal of Immunology
PG  - 5586--5590
VI  - 175
IP  - 9
4099  - http://www.jimmunol.org/content/175/9/5586.short
4100  - http://www.jimmunol.org/content/175/9/5586.full
SO  - J. Immunol.2005 Nov 01; 175
AB  - TNF apoptosis-inducing ligand is attracting considerable interest as a potential extrinsic tumor suppressor mechanism, although previous reports have conveyed somewhat contrasting views regarding the likely importance of this pathway. In this study, we provide the first evaluation of spontaneous tumor formation over the life span of TRAIL-deficient mice. Interestingly, >25% of these mice do develop lymphoid malignancies after 500 days of life. TRAIL suppressed the initiation and development of both tumors of lymphoid and stromal origin in the context of the loss of at least one p53 allele. Specific examination of the role of TRAIL in Her2/neu oncogene-driven mammary epithelial cancer revealed no critical role for TRAIL despite the inherent TRAIL sensitivity of such mammary carcinomas. Overall, the data indicate an important function of TRAIL in controlling carcinogenesis, but suggest that further examination of this pathway in epithelial malignancies is warranted.