RT Journal Article SR Electronic T1 Leptin in Immunology JF The Journal of Immunology JO J. Immunol. FD American Association of Immunologists SP 3137 OP 3142 DO 10.4049/jimmunol.174.6.3137 VO 174 IS 6 A1 Matarese, Giuseppe A1 Moschos, Stergios A1 Mantzoros, Christos S. YR 2005 UL http://www.jimmunol.org/content/174/6/3137.abstract AB Leptin is an adipokine which conveys information on energy availability. In humans, leptin influences energy homeostasis and regulates neuroendocrine function primarily in states of energy deficiency. As a cytokine, leptin also affects thymic homeostasis and, similar to other proinflammatory cytokines, leptin promotes Th1 cell differentiation and cytokine production. We review herein recent advances on the role of leptin in the pathophysiology of immune responses.