RT Journal Article
SR Electronic
T1 Leptin in Immunology
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 3137
OP 3142
DO 10.4049/jimmunol.174.6.3137
VO 174
IS 6
A1 Matarese, Giuseppe
A1 Moschos, Stergios
A1 Mantzoros, Christos S.
YR 2005
UL http://www.jimmunol.org/content/174/6/3137.abstract
AB Leptin is an adipokine which conveys information on energy availability. In humans, leptin influences energy homeostasis and regulates neuroendocrine function primarily in states of energy deficiency. As a cytokine, leptin also affects thymic homeostasis and, similar to other proinflammatory cytokines, leptin promotes Th1 cell differentiation and cytokine production. We review herein recent advances on the role of leptin in the pathophysiology of immune responses.