PT  - JOURNAL ARTICLE
AU  - Way, Sing Sing
AU  - Kollmann, Tobias R.
AU  - Hajjar, Adeline M.
AU  - Wilson, Christopher B.
TI  - Cutting Edge: Protective Cell-Mediated Immunity to <em>Listeria monocytogenes</em> in the Absence of Myeloid Differentiation Factor 88
AID  - 10.4049/jimmunol.171.2.533
DP  - 2003 Jul 15
TA  - The Journal of Immunology
PG  - 533--537
VI  - 171
IP  - 2
4099  - http://www.jimmunol.org/content/171/2/533.short
4100  - http://www.jimmunol.org/content/171/2/533.full
SO  - J. Immunol.2003 Jul 15; 171
AB  - In addition to their role in triggering innate immune responses, Toll-like receptors are proposed to play a key role in linking the innate and adaptive arms of the immune response. The majority of cellular responses downstream of Toll-like receptors are mediated through the adapter molecule myeloid differentiation factor 88 (MyD88), and mice with a targeted deletion of MyD88 are highly susceptible to bacterial infections, including primary infection with Listeria monocytogenes (LM). In contrast, herein we demonstrate that MyD88-deficient mice have only a modest impairment in their LM-specific CD4 T cell response, and no impairment in their CD8 T cell response following infection with ActA-deficient LM. Furthermore, CD8 T cells from immunized MyD88-deficient mice protected naive recipient mice following adoptive splenocyte transfer, and immunized MyD88-deficient mice were protected from infection with wild-type LM. These results indicate that adaptive immune responses can be generated and provide protective immunity in the absence of MyD88.