PT  - JOURNAL ARTICLE
AU  - Bondanza, Attilio
AU  - Zimmermann, Valérie S.
AU  - Dell’Antonio, Giacomo
AU  - Dal Cin, Elena
AU  - Capobianco, Annalisa
AU  - Sabbadini, Maria Grazia
AU  - Manfredi, Angelo A.
AU  - Rovere-Querini, Patrizia
TI  - Cutting Edge: Dissociation Between Autoimmune Response and Clinical Disease After Vaccination with Dendritic Cells
AID  - 10.4049/jimmunol.170.1.24
DP  - 2003 Jan 01
TA  - The Journal of Immunology
PG  - 24--27
VI  - 170
IP  - 1
4099  - http://www.jimmunol.org/content/170/1/24.short
4100  - http://www.jimmunol.org/content/170/1/24.full
SO  - J. Immunol.2003 Jan 01; 170
AB  - Autoimmunity represents a caveat to the use of dendritic cells (DCs) as adjuvant for human vaccines. We derived DCs from normal BALB/c mice or from mice prone to autoimmunity (NZB × NZW) F1. We allowed DCs to phagocytose apoptotic thymocytes and vaccinated syngeneic animals. All mice developed anti-nuclear and anti-dsDNA Abs. Autoantibodies in normal mice were transient, without clinical or histological features of autoimmunity or tissue involvement. In contrast, autoimmunity was maintained in susceptible mice, which underwent renal failure and precociously died. The data suggest that DC vaccination consistently triggers autoimmune responses. However, clinical autoimmunity develops in susceptible subjects only.