RT Journal Article
SR Electronic
T1 Cutting Edge: CD4 and CD8 T Cells Are Intrinsically Different in Their Proliferative Responses
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 1528
OP 1532
DO 10.4049/jimmunol.168.4.1528
VO 168
IS 4
A1 Foulds, Kathryn E.
A1 Zenewicz, Lauren A.
A1 Shedlock, Devon J.
A1 Jiang, Jiu
A1 Troy, Amy E.
A1 Shen, Hao
YR 2002
UL http://www.jimmunol.org/content/168/4/1528.abstract
AB In this study, we compared the proliferation and differentiation of Ag-specific CD4 and CD8 T cells following Listeria infection. Our results show that CD4 T cells responding to infection divide a limited number of times, with progeny exhibiting proliferative arrest in early divisions. Even with increased infectious doses, CD4 T cells display this restricted proliferative pattern and are not driven to undergo extensive clonal expansion. This is in striking contrast to CD8 T cells, which undergo extensive proliferation in response to infection. These differences are also evident when CD4 and CD8 T cells receive uniform anti-CD3 stimulation in vitro. Together, these results suggest that CD4 and CD8 T cells are programmed to undergo limited and extensive proliferation, respectively, to suit their function as regulator and effector cells.