RT Journal Article SR Electronic T1 Cutting Edge: CD4 and CD8 T Cells Are Intrinsically Different in Their Proliferative Responses JF The Journal of Immunology JO J. Immunol. FD American Association of Immunologists SP 1528 OP 1532 DO 10.4049/jimmunol.168.4.1528 VO 168 IS 4 A1 Foulds, Kathryn E. A1 Zenewicz, Lauren A. A1 Shedlock, Devon J. A1 Jiang, Jiu A1 Troy, Amy E. A1 Shen, Hao YR 2002 UL http://www.jimmunol.org/content/168/4/1528.abstract AB In this study, we compared the proliferation and differentiation of Ag-specific CD4 and CD8 T cells following Listeria infection. Our results show that CD4 T cells responding to infection divide a limited number of times, with progeny exhibiting proliferative arrest in early divisions. Even with increased infectious doses, CD4 T cells display this restricted proliferative pattern and are not driven to undergo extensive clonal expansion. This is in striking contrast to CD8 T cells, which undergo extensive proliferation in response to infection. These differences are also evident when CD4 and CD8 T cells receive uniform anti-CD3 stimulation in vitro. Together, these results suggest that CD4 and CD8 T cells are programmed to undergo limited and extensive proliferation, respectively, to suit their function as regulator and effector cells.