PT  - JOURNAL ARTICLE
AU  - Foulds, Kathryn E.
AU  - Zenewicz, Lauren A.
AU  - Shedlock, Devon J.
AU  - Jiang, Jiu
AU  - Troy, Amy E.
AU  - Shen, Hao
TI  - Cutting Edge: CD4 and CD8 T Cells Are Intrinsically Different in Their Proliferative Responses
AID  - 10.4049/jimmunol.168.4.1528
DP  - 2002 Feb 15
TA  - The Journal of Immunology
PG  - 1528--1532
VI  - 168
IP  - 4
4099  - http://www.jimmunol.org/content/168/4/1528.short
4100  - http://www.jimmunol.org/content/168/4/1528.full
SO  - J. Immunol.2002 Feb 15; 168
AB  - In this study, we compared the proliferation and differentiation of Ag-specific CD4 and CD8 T cells following Listeria infection. Our results show that CD4 T cells responding to infection divide a limited number of times, with progeny exhibiting proliferative arrest in early divisions. Even with increased infectious doses, CD4 T cells display this restricted proliferative pattern and are not driven to undergo extensive clonal expansion. This is in striking contrast to CD8 T cells, which undergo extensive proliferation in response to infection. These differences are also evident when CD4 and CD8 T cells receive uniform anti-CD3 stimulation in vitro. Together, these results suggest that CD4 and CD8 T cells are programmed to undergo limited and extensive proliferation, respectively, to suit their function as regulator and effector cells.