PT  - JOURNAL ARTICLE
AU  - Cretney, Erika
AU  - Takeda, Kazuyoshi
AU  - Yagita, Hideo
AU  - Glaccum, Moira
AU  - Peschon, Jacques J.
AU  - Smyth, Mark J.
TI  - Increased Susceptibility to Tumor Initiation and Metastasis in TNF-Related Apoptosis-Inducing Ligand-Deficient Mice
AID  - 10.4049/jimmunol.168.3.1356
DP  - 2002 Feb 01
TA  - The Journal of Immunology
PG  - 1356--1361
VI  - 168
IP  - 3
4099  - http://www.jimmunol.org/content/168/3/1356.short
4100  - http://www.jimmunol.org/content/168/3/1356.full
SO  - J. Immunol.2002 Feb 01; 168
AB  - We have previously implicated TNF-related apoptosis-inducing ligand (TRAIL) in innate immune surveillance against tumor development. In this study, we describe the use of TRAIL gene-targeted mice to demonstrate the key role of TRAIL in suppressing tumor initiation and metastasis. Liver and spleen mononuclear cells from TRAIL gene-targeted mice were devoid of TRAIL expression and TRAIL-mediated cytotoxicity. TRAIL gene-targeted mice were more susceptible to experimental and spontaneous tumor metastasis, and the immunotherapeutic value of α-galactosylceramide was diminished in TRAIL gene-targeted mice. TRAIL gene-targeted mice were also more sensitive to the chemical carcinogen methylcholanthrene. These results substantiated TRAIL as an important natural effector molecule used in the host defense against transformed cells.