PT  - JOURNAL ARTICLE
AU  - Nanki, Toshihiro
AU  - Lipsky, Peter E.
TI  - Cutting Edge: Stromal Cell-Derived Factor-1 Is a Costimulator for CD4<sup>+</sup> T Cell Activation
AID  - 10.4049/jimmunol.164.10.5010
DP  - 2000 May 15
TA  - The Journal of Immunology
PG  - 5010--5014
VI  - 164
IP  - 10
4099  - http://www.jimmunol.org/content/164/10/5010.short
4100  - http://www.jimmunol.org/content/164/10/5010.full
SO  - J. Immunol.2000 May 15; 164
AB  - Stromal cell-derived factor (SDF)-1 is a chemoattractant for T cells, precursor B cells, monocytes, and neutrophils. SDF-1α was also found to up-regulate expression of early activation markers (CD69, CD25, and CD154) by anti-CD3-activated CD4+ T cells. In addition, SDF-1α costimulated proliferation of CD4+ T cells and production of IL-2, IFN-γ, IL-4, and IL-10. Stimulation with SDF-1α alone did not induce activation marker expression, proliferation, or cytokine production by the CD4+ T cells. SDF-1α-mediated costimulation was blocked by anti-CXC chemokine receptor-4 mAb. RANTES also increased activation marker expression by anti-CD3-stimulated peripheral CD4+ T cells, but less effectively than SDF-1α did, and did not up-regulate IL-2 production and proliferation. These results indicate that SDF-1 and CXC chemokine receptor-4 interactions not only play a role in T cell migration but also provide potent costimulatory signals to Ag-stimulated T cells.