PT  - JOURNAL ARTICLE
AU  - Kim, S K
AU  - Reed, D S
AU  - Heath, W R
AU  - Carbone, F
AU  - Lefrançois, L
TI  - Activation and migration of CD8 T cells in the intestinal mucosa.
DP  - 1997 Nov 01
TA  - The Journal of Immunology
PG  - 4295--4306
VI  - 159
IP  - 9
4099  - http://www.jimmunol.org/content/159/9/4295.short
4100  - http://www.jimmunol.org/content/159/9/4295.full
SO  - J. Immunol.1997 Nov 01; 159
AB  - The activation of CD8 T cells was studied using transgenic mice expressing an MHC class I-restricted OVA-specific TCR (OT-I). Immunization of OT-I mice resulted in activation of lymph node T cells and up-regulation of expression of B220, CD11a, and CD44 and caused a preferential loss of mucosal-type T cells from the periphery. Immunization induced dramatic changes in intestinal lymphocytes, including the appearance of a CD11a high population that resembled peripheral T cells and induced a primary cytolytic response. Activation of adoptively transferred OT-I cells induced migration of CD8 T cells into the lamina propria and intraepithelial lymphocyte compartments. The results suggest that Ag presentation in the intestinal epithelium occurs, and that CD8 cells activated in the periphery can readily enter the mucosa during an ongoing immune response.