PT  - JOURNAL ARTICLE
AU  - Topham, D J
AU  - Tripp, R A
AU  - Doherty, P C
TI  - CD8+ T cells clear influenza virus by perforin or Fas-dependent processes.
DP  - 1997 Dec 01
TA  - The Journal of Immunology
PG  - 5197--5200
VI  - 159
IP  - 11
4099  - http://www.jimmunol.org/content/159/11/5197.short
4100  - http://www.jimmunol.org/content/159/11/5197.full
SO  - J. Immunol.1997 Dec 01; 159
AB  - Influenza virus infection is controlled in CD4-depleted mice that are also defective for the expression of either Fas (Fas-/-) or perforin (P-/-). Virus-immune P+/+ and P-/- CD8+ T cells can thus function in, respectively, a Fas-/- or Fas+/+ lung environment. The obvious question is whether the P-/- CD8+ set is effective in Fas-/- mice, a conclusion that would tend to favor cytokine secretion as the mode of virus clearance. Short term chimeras were made with P-/- bone marrow, P+/+ or P-/- T cells, and Fas+/+ or Fas-/- irradiated recipients. While the P+/+ CD8+ population cleared the virus from Fas+/+ and Fas-/- respiratory epithelium, the P-/- effectors were operational only if there was the potential for Fas to be expressed on radiation-resistant lung cells. Target cell destruction mediated via the Fas or perforin pathways is clearly the primary mechanism used by CD8+ T cells to terminate this viral pneumonia.