RT Journal Article
SR Electronic
T1 Therapeutic effect of DNA immunization of genetically susceptible mice infected with virulent Mycoplasma pulmonis.
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 2513
OP 2516
VO 158
IS 6
A1 Lai, W C
A1 Pakes, S P
A1 Ren, K
A1 Lu, Y S
A1 Bennett, M
YR 1997
UL http://www.jimmunol.org/content/158/6/2513.abstract
AB Genetically susceptible BALB/c mice were immunized i.m. with DNA for one or two Mycoplasma pulmonis Ags (A7-1, A8-1) beginning either 1 wk before (vaccination) or 1 wk after (treatment) intranasal infection with 5 x 10(4) CFU virulent M. pulmonis organisms. Immunization of mice by this method induced both humoral and cellular immunity to M. pulmonis, largely prevented infection (vaccination), and cleared an ongoing pneumonia over time (treatment). Only one Ag gene was required. Thus, DNA immunization is a potential treatment for infections and may be useful in instances when drug therapy may not be available or effective.