PT  - JOURNAL ARTICLE
AU  - Romani, L
AU  - Mencacci, A
AU  - Cenci, E
AU  - Spaccapelo, R
AU  - Del Sero, G
AU  - Nicoletti, I
AU  - Trinchieri, G
AU  - Bistoni, F
AU  - Puccetti, P
TI  - Neutrophil production of IL-12 and IL-10 in candidiasis and efficacy of IL-12 therapy in neutropenic mice.
DP  - 1997 Jun 01
TA  - The Journal of Immunology
PG  - 5349--5356
VI  - 158
IP  - 11
4099  - http://www.jimmunol.org/content/158/11/5349.short
4100  - http://www.jimmunol.org/content/158/11/5349.full
SO  - J. Immunol.1997 Jun 01; 158
AB  - Neutrophil defects predispose to severe fungal infections, yet the immunomodulatory role of these cells is poorly defined. The contribution of neutrophils to the early cytokine balance governing Th1 and Th2 cell development was examined in mice with candidiasis. Neutrophils secreted IL-12 and IL-10, correlating with the respective development of self-limiting (Th1-associated) and progressive (Th2-associated) disease. Exogenous IL-12 was effective in protecting neutropenic hosts susceptible to infection. These results suggest that 1) neutrophils, via their ability to release cytokines, play an active role in determining the qualitative development of the T cell response, and 2) their early role in anticandidal immunity can be replaced by exogenous IL-12.