PT  - JOURNAL ARTICLE
AU  - Yao, Z
AU  - Painter, S L
AU  - Fanslow, W C
AU  - Ulrich, D
AU  - Macduff, B M
AU  - Spriggs, M K
AU  - Armitage, R J
TI  - Human IL-17: a novel cytokine derived from T cells.
DP  - 1995 Dec 15
TA  - The Journal of Immunology
PG  - 5483--5486
VI  - 155
IP  - 12
4099  - http://www.jimmunol.org/content/155/12/5483.short
4100  - http://www.jimmunol.org/content/155/12/5483.full
SO  - J. Immunol.1995 Dec 15; 155
AB  - A cDNA encoding human IL-17 (hIL-17) was cloned from a CD4+ T cell library. The predicted 155-amino acids sequence contains an N-terminal signal peptide and exhibits 72% amino acid identity with HVS13, an open reading frame from a T-lymphotropic Herpesvirus saimiri, and 63% with murine CTLA8. High levels of hIL-17 were induced from primary peripheral blood CD4+ T cells upon stimulation. When expressed in CV1/EBNA cells, recombinant hIL-17 was secreted in both glycosylated and nonglycosylated forms. A hIL-17.Fc fusion protein and supernatants from cells transfected with hIL-17 induced IL-6 and IL-8 production and enhanced the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts.