PT  - JOURNAL ARTICLE
AU  - Carter, L L
AU  - Dutton, R W
TI  - Relative perforin- and Fas-mediated lysis in T1 and T2 CD8 effector populations.
DP  - 1995 Aug 01
TA  - The Journal of Immunology
PG  - 1028--1031
VI  - 155
IP  - 3
4099  - http://www.jimmunol.org/content/155/3/1028.short
4100  - http://www.jimmunol.org/content/155/3/1028.full
SO  - J. Immunol.1995 Aug 01; 155
AB  - IFN-gamma-secreting T1 and IL-5-secreting T2 subsets of CD8 effectors were generated in vitro using freshly isolated cells from wild-type and perforin knockout mice stimulated with allogeneic Ag-presenting cells. Both T1 and T2 effectors from wild-type mice exhibited perforin-mediated cytolysis. T1, but not T2, populations from perforin knockout mice displayed significant lysis by the Fas-mediated pathway. Th1 cells have recently been shown to be regulated by Fas and we speculate that Fas-mediated mechanisms are involved in the regulation of both Th1 and T1 populations of T cells.