RT Journal Article
SR Electronic
T1 Induction of B cell and T cell tolerance in vivo by anti-CD23 mAb.
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 3768
OP 3776
VO 152
IS 8
A1 Morris, S C
A1 Lees, A
A1 Holmes, J M
A1 Jeffries, R D
A1 Finkelman, F D
YR 1994
UL http://www.jimmunol.org/content/152/8/3768.abstract
AB T cell tolerance can be induced by B cell presentation of Ags to naive T cells. To further characterize this mechanism of T cell tolerance induction, we have investigated the effects of injecting mice with an intact rat IgG2a Ab, which binds to the B cell low-affinity Fc epsilon receptor (CD23), on the responsiveness of B cells and T cells to rat IgG2a. Our observations indicate that 1) intravenous, subcutaneous, or intraperitoneal injection of this Ab induces antigen-specific B cell and T cell tolerance; 2) both forms of tolerance are induced more completely by injection of rat IgG2a anti-CD23 mAb than by injection of an equal dose of a control rat IgG2a Ig; and 3) reduced responsiveness to Ag is seen as early as 1 to 3 days after anti-CD23 mAb injection and reaches maximum levels by 7 days after injection. Although tolerance induced by the injection of soluble proteins has been reported to be characterized by reduced production of IL-2 and IFN-gamma, but normal production of IL-4, injection of mice with rat IgG2a anti-mouse CD23 mAb greatly decreases the IL-4 response to a rat IgG2a immunogen that normally induces a large IL-4 response.