RT Journal Article
SR Electronic
T1 Engagement of MHC class I molecules induces cell adhesion via both LFA-1-dependent and LFA-1-independent pathways.
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 2045
OP 2049
VO 148
IS 7
A1 Spertini, F
A1 Chatila, T
A1 Geha, R S
YR 1992
UL http://www.jimmunol.org/content/148/7/2045.abstract
AB We here demonstrate that ligand binding to MHC class I molecules induces homotypic cell adhesion of lymphocytes and monocytes. mAb to beta 2-microglobulin caused sustained, largely LFA-1-independent adhesion whereas mAb to the MHC class I alpha H chain caused transient LFA-1-dependent adhesion. Both the protein kinase C inhibitor sphingosine and the tyrosine kinase inhibitor genistein abrogated MHC class I-mediated cellular adhesion. These results indicate that MHC class I molecules transduce signals that induce cell adhesion and suggest that interaction between MHC class I-restricted T cells and APC may result in reciprocal enhanced adhesiveness of these cells.