PT  - JOURNAL ARTICLE
AU  - Johnson, R M
AU  - Lancki, D W
AU  - Sperling, A I
AU  - Dick, R F
AU  - Spear, P G
AU  - Fitch, F W
AU  - Bluestone, J A
TI  - A murine CD4-, CD8- T cell receptor-gamma delta T lymphocyte clone specific for herpes simplex virus glycoprotein I.
DP  - 1992 Feb 15
TA  - The Journal of Immunology
PG  - 983--988
VI  - 148
IP  - 4
4099  - http://www.jimmunol.org/content/148/4/983.short
4100  - http://www.jimmunol.org/content/148/4/983.full
SO  - J. Immunol.1992 Feb 15; 148
AB  - The role of TCR-gamma delta T lymphocytes in immune responses is currently not well understood. TCR-gamma delta cells have a limited repertoire suggesting that TCR-gamma delta T a limited number of evolutionarily conserved Ag such as nonpolymorphic MHC and heat shock proteins. TCR-gamma delta T lymphocytes appear in enhanced numbers in skin lesions produced by Mycobacterium leprae and in the synovial fluid of joints affected by rheumatoid arthritis, raising the possibility that this subset of T lymphocytes may play a role in control of infectious processes and in autoimmune diseases. We report the identification of a TCR-gamma delta T cell clone isolated from a HSV-infected mouse that recognizes glycoprotein I of HSV type 1. Clone recognition of glycoprotein I does not appear to require the expression of MHC class I or class II gene products. These data suggest that TCR-gamma delta lymphocytes may play an important role in the immune response to viral infections.