PT  - JOURNAL ARTICLE
AU  - Biasi, G
AU  - Facchinetti, A
AU  - Panozzo, M
AU  - Zanovello, P
AU  - Chieco-Bianchi, L
AU  - Collavo, D
TI  - Moloney murine leukemia virus tolerance in anti-CD4 monoclonal antibody-treated adult mice.
DP  - 1991 Oct 01
TA  - The Journal of Immunology
PG  - 2284--2289
VI  - 147
IP  - 7
4099  - http://www.jimmunol.org/content/147/7/2284.short
4100  - http://www.jimmunol.org/content/147/7/2284.full
SO  - J. Immunol.1991 Oct 01; 147
AB  - Adult mice injected with Moloney murine leukemia virus (M-MuLV) 1 day after a short term treatment with anti-CD4 mAb developed T cell lymphomas, or sarcomas when rechallenged with Moloney murine sarcoma virus (M-MSV). Neoplastic development was correlated with virus spread, as thymic and peripheral T and B lymphocytes promptly expressed M-MuLV-induced Ag after virus introduction; no virus-specific CTL generation was detected in MLTC. This failure, which was selective for M-MuLV-induced Ag, persisted throughout the life span of the mice, and was not sustained by suppressor cell activity. The frequencies of splenic virus-specific CTL precursor varied in relation to time after virus injection; in the first postinjection month, frequencies were similar to those in nonimmune control mice, while at 4 mo post-virus exposure, they showed a striking reduction. These findings indicate that a transient functional impairment of CD4+ cells at the time of retrovirus injection provided the appropriate milieu for tolerance induction in both the peripheral mature and intrathymic T cell compartments.