RT Journal Article
SR Electronic
T1 Low natural antibody and low in vivo tumor resistance, in xid-bearing B-cell deficient mice.
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 3702
OP 3706
VO 142
IS 10
A1 Chow, D A
A1 Bennet, R D
YR 1989
UL http://www.jimmunol.org/content/142/10/3702.abstract
AB Evidence from correlative studies and Winn-type assays in syngeneic murine models has suggested that natural antibodies contribute to resistance against tumors in vivo. The B cell deficit associated with the X-linked immunodeficiency of CBA/N strain mice provided a genetic model in which to further test this question. RI-28, a radiation-induced T cell leukemia of the CBA/H strain acquired reduced levels of fluorescence-detected natural antibodies from the serum of X-linked immunodeficiency-bearing CBA/N and male (CBA/N x CBA/J) F1 mice compared with the serum from normals. Threshold s.c. inocula of the RI-28 appeared sooner and produced higher tumor frequencies in the X-linked immunodeficiency-bearing animals. This data coupled with the lack of correlating deficiencies in natural killer cell or activated macrophage activity provide the first genetic evidence for the hypothesis.