RT Journal Article
SR Electronic
T1 Immune response gene regulation of immunity to Plasmodium berghei sporozoites and circumsporozoite protein vaccines. Overcoming genetic restriction with whole organism and subunit vaccines.
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 3581
OP 3584
VO 142
IS 10
A1 Hoffman, S L
A1 Berzofsky, J A
A1 Isenbarger, D
A1 Zeltser, E
A1 Majarian, W R
A1 Gross, M
A1 Ballou, W R
YR 1989
UL http://www.jimmunol.org/content/142/10/3581.abstract
AB We conducted a series of experiments to define Ir gene regulation of the immune response to Plasmodium berghei sporozoites and circumsporozoite (CS) protein-derived subunit vaccines. The studies demonstrated that there is no apparent genetic restriction of the capacity to develop protective immunity against a large sporozoite challenge after immunization with irradiation-attenuated P. berghei sporozoites; that the Th response to (Asp-Pro-Ala-Pro-Pro-Asn-Ala-Asn)n, the predominant protective B epitope on the P. berghei CS protein, is genetically restricted and regulated by Class II genes (I-Ab) and by genes in the Class I region (H-2Dk) or telomeric to this region; and that this restriction can be overcome by immunization with a r protein including the entire P. berghei CS protein. The results support the development of full length human CS protein vaccines to take advantage of all potential T epitopes on this protein.