PT  - JOURNAL ARTICLE
AU  - Hoffman, S L
AU  - Berzofsky, J A
AU  - Isenbarger, D
AU  - Zeltser, E
AU  - Majarian, W R
AU  - Gross, M
AU  - Ballou, W R
TI  - Immune response gene regulation of immunity to Plasmodium berghei sporozoites and circumsporozoite protein vaccines. Overcoming genetic restriction with whole organism and subunit vaccines.
DP  - 1989 May 15
TA  - The Journal of Immunology
PG  - 3581--3584
VI  - 142
IP  - 10
4099  - http://www.jimmunol.org/content/142/10/3581.short
4100  - http://www.jimmunol.org/content/142/10/3581.full
SO  - J. Immunol.1989 May 15; 142
AB  - We conducted a series of experiments to define Ir gene regulation of the immune response to Plasmodium berghei sporozoites and circumsporozoite (CS) protein-derived subunit vaccines. The studies demonstrated that there is no apparent genetic restriction of the capacity to develop protective immunity against a large sporozoite challenge after immunization with irradiation-attenuated P. berghei sporozoites; that the Th response to (Asp-Pro-Ala-Pro-Pro-Asn-Ala-Asn)n, the predominant protective B epitope on the P. berghei CS protein, is genetically restricted and regulated by Class II genes (I-Ab) and by genes in the Class I region (H-2Dk) or telomeric to this region; and that this restriction can be overcome by immunization with a r protein including the entire P. berghei CS protein. The results support the development of full length human CS protein vaccines to take advantage of all potential T epitopes on this protein.