RT Journal Article
SR Electronic
T1 Molecular basis for the nonexpression of V beta 17 in some strains of mice.
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 2165
OP 2167
VO 141
IS 6
A1 Wade, T
A1 Bill, J
A1 Marrack, P C
A1 Palmer, E
A1 Kappler, J W
YR 1988
UL http://www.jimmunol.org/content/141/6/2165.abstract
AB The TCR alpha/beta variable element V beta 17a is expressed in all strains of mice carrying the V beta a complex in which about half of the V beta elements have been lost due to a large deletion. The mAb KJ23a detects V beta 17a containing alpha/beta receptors in these mice. Mouse strains with the V beta b complex carry a full complement of V beta genes including a structural gene for V beta 17 (V beta 17b), but no T cells reactive with KJ23a are present in these mice. Among random peripheral T cell hybridomas prepared from V beta b mice, occasional V beta 17b transcripts are found. The sequence of one of these transcripts reveals a single base difference from V beta 17a which results in a termination codon within the coding region inactivating the gene.