PT - JOURNAL ARTICLE AU - Kvale, D AU - Løvhaug, D AU - Sollid, L M AU - Brandtzaeg, P TI - Tumor necrosis factor-alpha up-regulates expression of secretory component, the epithelial receptor for polymeric Ig. DP - 1988 May 01 TA - The Journal of Immunology PG - 3086--3089 VI - 140 IP - 9 4099 - http://www.jimmunol.org/content/140/9/3086.short 4100 - http://www.jimmunol.org/content/140/9/3086.full SO - J. Immunol.1988 May 01; 140 AB - Secretory component (SC) is the receptor that facilitates transcytosis of polymeric IgA and polymeric IgM through secretory epithelial cells and into exocrine fluids. The present study showed that rTNF-alpha enhanced the cellular pool, membrane expression, and secretion of functionally SC in a human colonic carcinoma cell line (HT-29m2) which is known to express and process SC like normal glandular cells. TNF-alpha also up-regulated membrane expression of the constitutive HLA class I molecules, whereas the cells remained HLA class II-negative.