PT  - JOURNAL ARTICLE
AU  - Kvale, D
AU  - Løvhaug, D
AU  - Sollid, L M
AU  - Brandtzaeg, P
TI  - Tumor necrosis factor-alpha up-regulates expression of secretory component, the epithelial receptor for polymeric Ig.
DP  - 1988 May 01
TA  - The Journal of Immunology
PG  - 3086--3089
VI  - 140
IP  - 9
4099  - http://www.jimmunol.org/content/140/9/3086.short
4100  - http://www.jimmunol.org/content/140/9/3086.full
SO  - J. Immunol.1988 May 01; 140
AB  - Secretory component (SC) is the receptor that facilitates transcytosis of polymeric IgA and polymeric IgM through secretory epithelial cells and into exocrine fluids. The present study showed that rTNF-alpha enhanced the cellular pool, membrane expression, and secretion of functionally SC in a human colonic carcinoma cell line (HT-29m2) which is known to express and process SC like normal glandular cells. TNF-alpha also up-regulated membrane expression of the constitutive HLA class I molecules, whereas the cells remained HLA class II-negative.