RT Journal Article
SR Electronic
T1 Lymphokines regulate immunoglobulin isotype expression in an antigen-specific immune response.
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 2892
OP 2895
VO 136
IS 8
A1 Tesch, H
A1 Müller, W
A1 Rajewsky, K
YR 1986
UL http://www.jimmunol.org/content/136/8/2892.abstract
AB The control of immunoglobulin class switching appears to involve T cell-derived lymphokines. Such lymphokines have been shown to affect isotype expression in polyclonally activated B cells. We show in this paper that the same lymphokines similarly control isotype expression in an antigen-specific response acting in concert with a "T cell independent" antigen. In this situation, B cell growth factor II (BCGF II) enhances the production of antigen-specific IgM antibodies, whereas the production of antigen-specific IgG1 antibodies is only observed in the presence of B cell differentiation factor gamma (BCDF gamma). These results suggest that these lymphokines (and perhaps additional ones) are involved in the control of isotype expression in antigen-specific responses.