PT  - JOURNAL ARTICLE
AU  - Tesch, H
AU  - Müller, W
AU  - Rajewsky, K
TI  - Lymphokines regulate immunoglobulin isotype expression in an antigen-specific immune response.
DP  - 1986 Apr 15
TA  - The Journal of Immunology
PG  - 2892--2895
VI  - 136
IP  - 8
4099  - http://www.jimmunol.org/content/136/8/2892.short
4100  - http://www.jimmunol.org/content/136/8/2892.full
SO  - J. Immunol.1986 Apr 15; 136
AB  - The control of immunoglobulin class switching appears to involve T cell-derived lymphokines. Such lymphokines have been shown to affect isotype expression in polyclonally activated B cells. We show in this paper that the same lymphokines similarly control isotype expression in an antigen-specific response acting in concert with a "T cell independent" antigen. In this situation, B cell growth factor II (BCGF II) enhances the production of antigen-specific IgM antibodies, whereas the production of antigen-specific IgG1 antibodies is only observed in the presence of B cell differentiation factor gamma (BCDF gamma). These results suggest that these lymphokines (and perhaps additional ones) are involved in the control of isotype expression in antigen-specific responses.