PT  - JOURNAL ARTICLE
AU  - Woda, B A
AU  - Like, A A
AU  - Padden, C
AU  - McFadden, M L
TI  - Deficiency of phenotypic cytotoxic-suppressor T lymphocytes in the BB/W rat.
DP  - 1986 Feb 01
TA  - The Journal of Immunology
PG  - 856--859
VI  - 136
IP  - 3
4099  - http://www.jimmunol.org/content/136/3/856.short
4100  - http://www.jimmunol.org/content/136/3/856.full
SO  - J. Immunol.1986 Feb 01; 136
AB  - The BB/W rat is currently the best model of type I (insulin dependent diabetes). Even though this rat develops an autoimmune disease, they are immune deficient. In this study we have demonstrated the almost complete absence of the OX 8+, OX 19+ T cytotoxic/suppressor population in diabetes prone and acute diabetic rats. This population is present in the diabetes resistant W line. The diabetes prone and acute diabetic rats have a relative increase in OX 8+, OX 19- natural killer (NK) cells. Our data suggests that virtually all OX 8+ cells in diabetes prone and acute diabetic animals are phenotypic NK cells.