RT Journal Article
SR Electronic
T1 Rodent IgE-binding factor genes are members of an endogenous, retrovirus-like gene family.
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 4283
OP 4290
VO 136
IS 11
A1 Moore, K W
A1 Jardieu, P
A1 Mietz, J A
A1 Trounstine, M L
A1 Kuff, E L
A1 Ishizaka, K
A1 Martens, C L
YR 1986
UL http://www.jimmunol.org/content/136/11/4283.abstract
AB Synthesis of IgE by B lymphocytes can be regulated by soluble lymphocyte factors which have affinity for the Fc region of IgE (IgE-binding factors). In previous studies, we identified cDNA clones encoding rodent IgE-binding factors by direct expression in transfected mammalian cells. Here we show that IgE-binding factor cDNA clone 8.3 is a member of the endogenous, retrovirus-like intracisternal A-particle gene family of the mouse. This conclusion is supported by blot hybridization, DNA sequence comparisons, heteroduplex analysis, and immunochemical cross-reactivity of the encoded proteins. The results identify a member of this highly reiterated gene family with a role in regulation of the allergic immune response.