PT  - JOURNAL ARTICLE
AU  - Moore, K W
AU  - Jardieu, P
AU  - Mietz, J A
AU  - Trounstine, M L
AU  - Kuff, E L
AU  - Ishizaka, K
AU  - Martens, C L
TI  - Rodent IgE-binding factor genes are members of an endogenous, retrovirus-like gene family.
DP  - 1986 Jun 01
TA  - The Journal of Immunology
PG  - 4283--4290
VI  - 136
IP  - 11
4099  - http://www.jimmunol.org/content/136/11/4283.short
4100  - http://www.jimmunol.org/content/136/11/4283.full
SO  - J. Immunol.1986 Jun 01; 136
AB  - Synthesis of IgE by B lymphocytes can be regulated by soluble lymphocyte factors which have affinity for the Fc region of IgE (IgE-binding factors). In previous studies, we identified cDNA clones encoding rodent IgE-binding factors by direct expression in transfected mammalian cells. Here we show that IgE-binding factor cDNA clone 8.3 is a member of the endogenous, retrovirus-like intracisternal A-particle gene family of the mouse. This conclusion is supported by blot hybridization, DNA sequence comparisons, heteroduplex analysis, and immunochemical cross-reactivity of the encoded proteins. The results identify a member of this highly reiterated gene family with a role in regulation of the allergic immune response.