RT Journal Article
SR Electronic
T1 LFA-1 membrane molecule in the regulation of homotypic adhesions of human B lymphocytes.
JF The Journal of Immunology
JO J. Immunol.
FD American Association of Immunologists
SP 9
OP 11
VO 135
IS 1
A1 Mentzer, S J
A1 Gromkowski, S H
A1 Krensky, A M
A1 Burakoff, S J
A1 Martz, E
YR 1985
UL http://www.jimmunol.org/content/135/1/9.abstract
AB We report here that MAb to human LFA-1 inhibit spontaneous homotypic adhesions of human B lymphocytes. This is, to our knowledge, the first report of a MAb that inhibits human homotypic intercellular adhesions for any cell type. LFA-1 has previously been recognized as a molecule capable of regulating specific immunologic adhesions between T lymphocytes and antigen-bearing target cells. The present findings show that the role of LFA-1 is not limited to adhesions initiated by specific immunologic recognition. The results indicate that the LFA-1 molecule is capable of regulating lymphocyte adhesions, possibly because it is a direct participant in adhesion formation.